Orthogonal RNA replication enables directed evolution and Darwinian adaptation in mammalian cells
Liang Ma, Yihan Lin
Topics & Concepts
Synthetic biologyBiologyDirected evolutionRNA interferenceRNAComputational biologyRNA-dependent RNA polymeraseMutagenesisCell biologyGeneticsGeneMutationMutantCRISPR and Genetic EngineeringRNA and protein synthesis mechanismsRNA Interference and Gene Delivery