Kynurenine 3-monooxygenase deficiency induces depression-like behavior via enhanced antagonism of α7 nicotinic acetylcholine receptors by kynurenic acid
Yuko Mori, Akihiro Mouri, Kazuo Kunisawa, Mami Hirakawa, Hisayoshi Kubota, Aika Kosuge, Moe Niijima, Masaya Hasegawa, Hitomi Kurahashi, Reiko Murakami, Masato Hoshi, T. Nakano, Suwako Fujigaki, Hidetsugu Fujigaki, Yasuko Yamamoto, Toshitaka Nabeshima, Kuniaki Saito
Topics & Concepts
Kynurenic acidMethyllycaconitineBehavioural despair testKynurenineEndocrinologyInternal medicineKynurenine pathwayChemistryNicotineQuinolinic acidNicotinic agonistPharmacologyNicotinic acetylcholine receptorGlutamate receptorReceptorBiochemistryBiologyMedicineTryptophanHippocampusAntidepressantAmino acidTryptophan and brain disordersStress Responses and CortisolMental Health Research Topics