Characterization of Neuronal RNA Modifications during Non-associative Learning in <i>Aplysia</i> Reveals Key Roles for tRNAs in Behavioral Sensitization
Kevin D. Clark, Colin A. Lee, Rhanor Gillette, Jonathan V. Sweedler
Abstract
A), at significantly higher levels in trained subjects. We report that tRNAs, and their modifications, correlate with increased polyglutamine synthesis and excitability in neurons, characterizing the first link between noncoding RNA modifications and non-associative learning.
Topics & Concepts
AplysiaRNANeuroscienceAssociative learningBiologyTransfer RNAN6-MethyladenosineSynaptic plasticityComputational biologyBiochemistryGeneMethylationMethyltransferaseReceptorRNA modifications and cancerRNA Research and SplicingRNA and protein synthesis mechanisms