Preparation of hydrogel microsphere and its application in articular cartilage injury
Zehua Wang, Xiaoxia Li, Yaping Jiang, Tingyu Wu, Sijia Guo, Tao Li
Abstract
In recent years, hydrogel microspheres have garnered significant attention due to their unique structure and functionality, demonstrating substantial potential in articular cartilage injury repair. This paper provides a comprehensive overview of current strategies for cartilage injury repair and summarizes the materials and preparation methods of hydrogel microspheres. Furthermore, it highlights the multiple roles of hydrogel microspheres in cartilage repair, including inflammation control, regulation of chondrocyte metabolism, drug and cell delivery, lubrication improvement, and recruitment of endogenous stem cells. Finally, the paper discusses the application prospects of hydrogel microspheres, identifies current limitations and challenges, and offers insights to guide future research and practical applications in cartilage injury repair. • Hydrogel microspheres in the repair of articular cartilage injuries are summarized. • Various methods for the preparation of hydrogel microspheres are described. • The role played by hydrogel microspheres in articular cartilage damage is summarized.