Cumulative fluid balance and mortality in elderly patients with acute kidney injury requiring continuous renal-replacement therapy: a multicenter prospective cohort study
Jong Hyun Jhee, Jae Yoon Park, Jung Nam An, Dong Ki Kim, Kwon Wook Joo, Yun Kyu Oh, Chun Soo Lim, Yon Su Kim, Seung Hyeok Han, Tae‐Hyun Yoo, Shin‐Wook Kang, Jung Pyo Lee, Jung Tak Park
Abstract
BACKGROUND: The effect of fluid balance on outcomes in elderly patients with acute kidney injury (AKI) requiring continuous renal-replacement therapy (CRRT) is not explained well. We investigated outcomes according to cumulative fluid balance (CFB) in elderly patients with AKI undergoing CRRT. METHODS: A total of 607 patients aged 65 years or older who started CRRT due to AKI were enrolled and stratified into two groups (fluid overload [FO] vs. no fluid overload [NFO]) based on the median CFB value for 72 hours before CRRT initiation. Propensity score-matching analysis was performed. RESULTS: < 0.001). Among survivors, both the duration of CRRT and the total duration of hospitalization from CRRT initiation showed no difference between the FO and NFO groups. CONCLUSION: A higher CFB value is associated with an increased risk of mortality in elderly patients with AKI requiring CRRT.