The Current status of steroid-refractory immune-checkpoint-inhibitor-related hepatotoxicity
Hui Xing, Yang Wang, Bo Qu, Qiang Wei, Cuihua Li, Chao Pan, Hui Li
Abstract
ICI-related hepatotoxicity (IRH) is becoming more and more common as immune checkpoint inhibitors (ICIs) have begun to be increasingly approved and used in combination with other anti-tumor drugs worldwide. Steroids are the first choice for the treatment of IRH, but the subsequent optimal treatment algorithm remains unclear if the disease progresses to steroid-refractory IRH. Therefore, in this paper we reviewed all the pertinent literature on steroid-refractory IRH to the greatest extent possible in an attempt to provide information on which to base an update of the treatment algorithm for steroid-refractory IRH.
Topics & Concepts
SteroidRefractory (planetary science)MedicineImmune checkpointSteroid useImmune systemBioinformaticsPharmacologyInternal medicineImmunologyImmunotherapyBiologyHormoneAstrobiologyCancer Immunotherapy and BiomarkersLung Cancer Treatments and MutationsLung Cancer Research Studies