Phase I metabolic profiling and unexpected reactive metabolites in human liver microsome incubations of X-376 using LC-MS/MS: bioactivation pathway elucidation and<i>in silico</i>toxicity studies of its metabolites
Mohamed W. Attwa, Adnan A. Kadi, Ali S. Abdelhameed
Abstract
metabolic profiling or structural characterization and toxicological properties of the generated metabolites for X-376.
Topics & Concepts
In silicoMicrosomeChemistryMetabolic pathwayHuman liverToxicityChromatographyBiochemistryMetabolismEnzymeOrganic chemistryGeneMetabolomics and Mass Spectrometry StudiesPharmacogenetics and Drug MetabolismComputational Drug Discovery Methods