Cabazitaxel-loaded redox-responsive nanocarrier based on <scp>d</scp>-alpha-tocopheryl-chitosan and hyaluronic acid for improved anti-tumor efficacy in DMBA-induced breast cancer model
Abhishek Jha, Manish Kumar, Pooja Goswami, Kanchan Bharti, Manjit Manjit, Ashutosh Gupta, Sudheer Moorkoth, Biplob Koch, Brahmeshwar Mishra
Abstract
The study involved the formulation and evaluation of cabazitaxel loaded d -alpha-tocopheryl succinate/chitosan conjugate (CSVE) and hyaluronic acid (HA) based redox-responsive nanoparticle crosslinked using 3,3′-dithiodipropionic acid (DTPA).
Topics & Concepts
Hyaluronic acidNanocarriersChitosanCabazitaxelChemistryPharmacologyDMBACancer researchMedicineCancerDrugInternal medicineBiochemistryAndrogen deprivation therapyProstate cancerCarcinogenesisAnatomyNanoplatforms for cancer theranosticsNanoparticle-Based Drug DeliveryAdvanced Nanomaterials in Catalysis