Artemisia argyi exhibits anti-aging effects through decreasing the senescence in aging stem cells
Tsung‐Jung Ho, Debakshee Goswami, Wei‐Wen Kuo, Chia‐Hua Kuo, Shih Cheng Yen, Pi‐Yu Lin, Shinn‐Zong Lin, Dennis Jine‐Yuan Hsieh, Marthandam Asokan Shibu, Chih‐Yang Huang
Abstract
study showed the protective effect of AAW in telomere shortening and helps in maintaining a balance in the expression of anti-aging protein Klotho and TERT. AAW effectively reduced mitochondrial superoxide and also provided a protective shield against senescence markers like over-expression of p21 and formation of double strand breaks, which is known to cause premature aging. Moreover, animal studies indicated that AAW promoted the expression of Klotho in naturally aging rats. In addition, AAW successfully restored the decline cardiac function and improved the grip strength and memory of aging rat. These findings showed that therapeutic targeting of senescent stem cells by AAW restored stem cell homeostasis and improves overall health.