Efficacy of HSV-TK/GCV system suicide gene therapy using SHED expressing modified HSV-TK against lung cancer brain metastases
Tomoya Oishi, Masahiko Ito, Shinichiro Koizumi, Makoto Horikawa, Taisuke Yamamoto, Satoru Yamagishi, Tomohiro Yamasaki, Tetsuro Sameshima, Tetsuro Suzuki, Haruhiko Sugimura, Hiroki Namba, Kazuhiko Kurozumi
Abstract
variant is suitable for establishing therapeutic cells and that intratumoral injection of SHED-TK followed by GCV administration may be a useful strategy for therapeutic approaches.
Topics & Concepts
Suicide geneBystander effectThymidine kinaseCancer researchGanciclovirGenetic enhancementMesenchymal stem cellLung cancerMedicineIn vivoHerpes simplex virusBiologyImmunologyPathologyVirusGeneHuman cytomegalovirusBiotechnologyBiochemistryVirus-based gene therapy researchMesenchymal stem cell researchRNA Interference and Gene Delivery