Organocatalysed one-pot three component synthesis of 3,3′-disubstituted oxindoles featuring an all-carbon quaternary center and spiro[2<i>H</i>-pyran-3,4′-indoline]
Chandrakant B. Nichinde, Baliram R. Patil, Suryakant S. Chaudhari, Bhupendra P. Mali, Rajesh G. Gonnade, Anil K. Kinage
Abstract
-pyran-3,4'-indoline] through consecutive Knoevenagel condensation/Michael addition/reduction/cyclization reactions from readily available isatin derivatives, malononitrile, and ketones. The present methodology presents several advantages, including simple reaction set-up, short reaction times, and easy to work-up. Also, this strategy offers broad substrate scope with excellent yields and high atom economy, under mild reaction conditions.
Topics & Concepts
IndolineQuaternary carbonPyranComponent (thermodynamics)Center (category theory)Carbon fibersChemistryStereochemistryOrganic chemistryMathematicsCatalysisPhysicsCrystallographyEnantioselective synthesisAlgorithmComposite numberThermodynamicsAsymmetric Synthesis and CatalysisSynthesis of Indole DerivativesMulticomponent Synthesis of Heterocycles