Litcius/Paper detail

<i>Alu</i> complementary DNA is enriched in atrophic macular degeneration and triggers retinal pigmented epithelium toxicity via cytosolic innate immunity

Shin‐ichi Fukuda, Siddharth Narendran, Akhil Varshney, Yosuke Nagasaka, Shao-Bin Wang, Kameshwari Ambati, Ivana Apicella, Felipe Pereira, Benjamin J. Fowler, Tetsuhiro Yasuma, Shuichiro Hirahara, Reo Yasuma, Peirong Huang, Praveen Yerramothu, Ryan D. Makin, Mo Wang, Kirstie Baker, Kenneth M. Marion, Xiwen Huang, Elmira Baghdasaryan, Meenakshi Ambati, Vidya L. Ambati, Daipayan Banerjee, Vera L. Bonilha, Genrich V. Tolstonog, Ulrike Held, Yuichiro Ogura, Hiroko Terasaki, Tetsuro Oshika, Deepak Bhattarai, Kyung Bo Kim, Sanford H. Feldman, J. Ignacio Aguirre, David R. Hinton, Nagaraj Kerur, Srinivas R. Sadda, Gerald G. Schumann, Bradley D. Gelfand, Jayakrishna Ambati

2021Science Advances51 citationsDOIOpen Access PDF

Abstract

cDNA toxicity, identifying inflammasome activation as the terminal effector of RPE degeneration.

Topics & Concepts

Alu elementBiologyRetinal pigment epitheliumComplementary DNAInflammasomeInnate immune systemAIM2Cell biologyMacular degenerationMolecular biologyRetinalImmunologyGeneGeneticsMedicineBiochemistryInflammationHuman genomeGenomeImmune systemOphthalmologyinterferon and immune responsesCytomegalovirus and herpesvirus researchNeutrophil, Myeloperoxidase and Oxidative Mechanisms