Metal-chelating benzothiazole multifunctional compounds for the modulation and <sup>64</sup> Cu PET imaging of Aβ aggregation
Yiran Huang, Hong-Jun Cho, Nilantha Bandara, Liang Sun, Diana Tran, Buck E. Rogers, Liviu M. Mirica
Abstract
is shown to have a significant brain uptake of up to 0.99 ± 0.04 %ID per g. Overall, by evaluating the various properties of these MFCs valuable structure-activity relationships were obtained that should aid the design of improved therapeutic and diagnostic agents for AD.
Topics & Concepts
BenzothiazoleChelationChemistryMetalCombinatorial chemistryNuclear chemistryInorganic chemistryOrganic chemistryAlzheimer's disease research and treatmentsNeuroscience and Neuropharmacology ResearchComputational Drug Discovery Methods