Deeper insight into the role of IL-17 in the relationship beween hypertension and intestinal physiology
Zejun Yang, Tiantian Wang, Boya Wang, Han Gao, Chengwei He, Hongwei Shang, Xin Lü, Ying Wang, Jingdong Xu
Abstract
With the incidence of hypertension increasing worldwide, more and more the mechanisms of hypertension from the perspective of immunity have found. Intestinal microbiota as well as its metabolites relationship with hypertension has attracted great attention from both clinicians and investigators. However, the associations of hypertension with lesions of a large number of immune factors including IL-17, MCP-1, IL-6, TGF-β, IL-10 and others have not been fully characterized. In this review, after introducing the immune factors as the most potent anti/pro-hypertension agents known, we provide detailed descriptions of the IL-17 involved in the pathology of hypertension, pointing out the underlying mechanisms and suggesting the clinical indications.