Reproducibility and Repeatability of US Shear-Wave and Transient Elastography in Nonalcoholic Fatty Liver Disease
Theodore T. Pierce, Arinc Ozturk, Sarah P. Sherlock, Guilherme Moura Cunha, X J Wang, Qian Li, David Hunt, Michael S. Middleton, Marian Martin, Kathleen E. Corey, Hannah Edenbaum, Sudha S. Shankar, H.O. Heymann, Tania N. Kamphaus, Roberto A. Calle, Yesenia Covarrubias, Rohit Loomba, Nancy A. Obuchowski, Arun J. Sanyal, Claude B. Sirlin, Kathryn J. Fowler, Anthony E. Samir
Abstract
This prospective study defines expected US elastography measurement variability to guide clinical interpretation, enable diagnostic enrichment in clinical trials, and support U.S. Food and Drug Administration biomarker validation for nonalcoholic fatty liver disease.
Topics & Concepts
MedicineNonalcoholic fatty liver diseaseTransient elastographyReproducibilityRepeatabilityShear (geology)Transient (computer programming)Biomedical engineeringRadiologyPathologyFatty liverDiseaseInternal medicineCirrhosisComposite materialStatisticsLiver fibrosisOperating systemComputer scienceMathematicsMaterials scienceLiver Disease Diagnosis and TreatmentCardiovascular Disease and AdiposityLipid metabolism and disorders