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Limonin ameliorates acetaminophen-induced hepatotoxicity by activating Nrf2 antioxidative pathway and inhibiting NF-κB inflammatory response via upregulating Sirt1

Runyu Yang, Changqin Song, Jiaxi Chen, Lvqi Zhou, Xiubo Jiang, Xiaomei Cao, Yang Sun, Qi Zhang

2020Phytomedicine109 citationsDOI

Topics & Concepts

NF-κBPharmacologyChemistryNFKB1AcetaminophenInflammationInflammatory responseAnti-inflammatorySignal transductionMedicineImmunologyBiochemistryTranscription factorGeneDrug-Induced Hepatotoxicity and ProtectionChemotherapy-induced organ toxicity mitigationLiver physiology and pathology
Limonin ameliorates acetaminophen-induced hepatotoxicity by activating Nrf2 antioxidative pathway and inhibiting NF-κB inflammatory response via upregulating Sirt1 | Litcius