Universal cell membrane camouflaged nano-prodrugs with right-side-out orientation adapting for positive pathological vascular remodeling in atherosclerosis
Xian Qin, Li Zhu, Yuan Zhong, Yi Wang, Xiao‐San Luo, Jiawei Li, Fei Yan, Gui-Cheng Wu, Juhui Qiu, Guixue Wang, Kai Qu, Kun Zhang, Wei Wu
Abstract
experimental results confirm that OEM-ETBNPs are able to inhibit cellular lipid uptake and simultaneously promote intracellular lipid efflux, regulating the positive cellular phenotypic conversion. This finding offers a versatile platform for the biomedical applications of universal cell membrane camouflaging biomimetic nanotechnology.
Topics & Concepts
PathologicalCellProdrugCell biologyMembraneCell membraneBiophysicsPhenotypeChemistryCoupling (piping)Materials scienceBiologyBiochemistryMedicineInternal medicineGeneMetallurgyNanoplatforms for cancer theranosticsNanoparticle-Based Drug DeliverySupramolecular Self-Assembly in Materials