Firm evidence for the detoxification of senecionine-induced hepatotoxicity via N-glucuronidation in UGT1A4–humanized transgenic mice
Yan Chen, Weiqian Wang, Xia-Li Jia, Changhong Wang, Li Yang, Zhengtao Wang, Aizhen Xiong
Topics & Concepts
GlucuronidationToxicityPharmacologyDetoxification (alternative medicine)GlucuronosyltransferasePyrrolizidinePyrrolizidine alkaloidDrug metabolismChemistryBiochemistryBiologyMicrosomeMedicineDrugEnzymeStereochemistryPathologyOrganic chemistryAlternative medicinePlant Toxicity and Pharmacological PropertiesDrug-Induced Hepatotoxicity and ProtectionPharmacogenetics and Drug Metabolism