Moving microcapillary antibiotic susceptibility testing (mcAST) towards the clinic: unravelling kinetics of detection of uropathogenic <i>E. coli</i>, mass-manufacturing and usability for detection of urinary tract infections in human urine
Sarah Needs, Jérémy Pivetal, Jessica H. Hayward, Stephen P. Kidd, HoYin Lam, Tai The Diep, Kirandeep K. Gill, Martin J. Woodward, Nuno M. Reis, Alexander D. Edwards
Abstract
of uropathogenic bacteria in the urine sample. In addition, we show for the first time that use of air-drying for mass-manufacturing and deposition of AST reagents within the inner surface of mcAST strips matches results obtained with standard AST methods. These results take mcAST a step closer to clinical application, for example as PoC support for antibiotic prescription decisions within a day.
Topics & Concepts
UrineUrinary systemUsabilityAntibioticsMedicineMicrobiologyComputer scienceInternal medicineBiologyHuman–computer interactionBacterial Identification and Susceptibility TestingUrinary Tract Infections ManagementClostridium difficile and Clostridium perfringens research