Loss of β-catenin via activated GSK3β causes diabetic retinal neurodegeneration by instigating a vicious cycle of oxidative stress-driven mitochondrial impairment
Xing‐sheng Shu, Huazhang Zhu, Xiaoyan Huang, Yangfan Yang, Dandan Wang, Yiling Zhang, Weizhen Zhang, Ying Ying
Abstract
abolished the protective effect of GSK3β inhibition on diabetic RGCs by suppression of antioxidant scavengers and augmentation of oxidative stress-driven mitochondrial lesion. Thus, our data identify β-catenin as a part of an endogenous protective system in diabetic RGCs and a promising target to develop intervention strategies that protect RGCs from neurodegeneration at early onset of diabetic retinopathy.
Topics & Concepts
Oxidative stressNeurodegenerationRetinalMedicineNeuroscienceEndocrinologyBiologyInternal medicineOphthalmologyDiseaseWnt/β-catenin signaling in development and cancerNuclear Receptors and SignalingCerebrovascular and genetic disorders