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Dried Blood Spot PCR for Detection of Congenital Cytomegalovirus Infection and Disease

Mark R. Schleiss, Erin Osterholm, Ryan Shanley, Nelmary Hernandez-Alvarado, Emily Graupmann, Rebecca Kruc, Rick J. Jansen, Melissa J. Polonenko, Hannah Herd, Claudia Fernández-Alarcón, Mark Blackstad, Sondra D. Rosendahl, Kirsten Coverstone, Mark McCann, Abbey Sidebottom, Whitney Wunderlich, Sasha Strul, Kathleen A. Kulus, Sheila C. Dollard, Tatiana M. Lanzieri

2025JAMA Network Open6 citationsDOIOpen Access PDF

Abstract

This cohort study evaluates the performance of dried blood spot polymerase chain reaction (PCR) testing for the identification of congenital cytomegalovirus among infants in Minnesota.

Topics & Concepts

Dried blood spotCytomegalovirusPolymerase chain reactionMedicineDried bloodVirologyCohortCytomegalovirus infectionReal-time polymerase chain reactionHuman cytomegalovirusBiologyHerpesviridaeVirusInternal medicineViral diseaseGeneGeneticsChemistryChromatographyCytomegalovirus and herpesvirus researchParvovirus B19 Infection StudiesHerpesvirus Infections and Treatments