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Negative Allosteric Modulation of Gamma-Aminobutyric Acid A Receptors at α5 Subunit–Containing Benzodiazepine Sites Reverses Stress-Induced Anhedonia and Weakened Synaptic Function in Mice

Timothy A. Troppoli, Panos Zanos, Polymnia Georgiou, Todd D. Gould, Uwe Rudolph, Scott M. Thompson

2021Biological Psychiatry29 citationsDOIOpen Access PDF

Topics & Concepts

AnhedoniaGABAA receptorAMPA receptorHippocampal formationAllosteric regulationgamma-Aminobutyric acidNeuroscienceBenzodiazepineKnockout mouseInternal medicineHippocampusEndocrinologyNMDA receptorChemistryAllosteric modulatorPharmacologyBiologyReceptorMedicineDopamineNeuroscience and Neuropharmacology ResearchTreatment of Major DepressionNeurotransmitter Receptor Influence on Behavior
Negative Allosteric Modulation of Gamma-Aminobutyric Acid A Receptors at α5 Subunit–Containing Benzodiazepine Sites Reverses Stress-Induced Anhedonia and Weakened Synaptic Function in Mice | Litcius