Breast cancer animal models and applications
Li Zeng, 中国科学院昆明动物研究所，中国科学院与云南省动物模型与人类疾病机制重点实验室，云南 昆明650223，中国, Wěi Li, Ceshi Chen, 中国科学院大学昆明生命科学学院，云南 昆明650204，中国, 中国科学院昆明动物研究所，KIZ-CUHK常见疾病生物资源与分子生物学联合研究室，云南昆明650223，中国
Abstract
Breast cancer is the most common malignancy in women. Basic and translational breast cancer research relies heavily on experimental animal models. Ideally, such models for breast cancer should have commonality with human breast cancer in terms of tumor etiology, biological behavior, pathology, and response to therapeutics. This review introduces current progress in different breast cancer experimental animal models and analyzes their characteristics, advantages, disadvantages, and potential applications. Finally, we propose future research directions for breast cancer animal models.