The N-terminal autoinhibitory module of the A1 domain in von Willebrand factor stabilizes the mechanosensor catch bond
Yunduo Charles Zhao, Haoqing Wang, Yao Wang, Jizhong Lou, Lining Arnold Ju
Abstract
-A1). Notably, such bi-variable transition happened at low temperatures or high pH levels, whereas Q1238-E1260 stabilized the 1238-A1 catch bond regardless of the environmental factors. The physiological study was complemented by platelet perfusion assays using microfluidics. Taken together, these studies provide new mechanobiology on how N-AIM serves as a mechano-regulator of VWF activity, which inspires future VWF-A1 dependent antithrombotic approaches.
Topics & Concepts
Terminal (telecommunication)Von Willebrand factorDomain (mathematical analysis)Computer scienceCell biologyComputer networkBiologyMathematicsImmunologyPlateletMathematical analysisErythrocyte Function and PathophysiologyBlood disorders and treatmentsNeutrophil, Myeloperoxidase and Oxidative Mechanisms