A conserved rRNA switch is central to decoding site maturation on the small ribosomal subunit
Andreas Schedlbauer, Idoia Iturrioz, Borja Ochoa-Lizarralde, Tammo Diercks, Jorge P. López‐Alonso, José Luis Lavín, Tatsuya Kaminishi, Retina Çapuni, Neha Dhimole, Elisa de Astigarraga, David Gil‐Carton, Paola Fucini, Sean R. Connell
Abstract
ribosomal RNA central to decoding site maturation and suggests both a sequential order of action and molecular mechanisms for the assembly factors in coordinating and controlling this switch. Structural and mechanistic parallels between bacterial and eukaryotic systems indicate common folding features inherent to all ribosomes.
Topics & Concepts
Ribosomal RNAComputational biologyFolding (DSP implementation)BiologyProtein subunitRibosomal proteinGeneticsRibosomeRNAGeneEngineeringElectrical engineeringRNA and protein synthesis mechanismsRNA modifications and cancerGenomics and Chromatin Dynamics