Dysregulation of antimicrobial peptide expression distinguishes Alzheimer’s disease from normal aging
Min Wang, I‐Feng Peng, Simin Li, Xianda Hu
Abstract
concentration. In conclusion, our study provides evidence for abnormal gene expression of AMPs in AD flies with age, which is distinct from the expression profiles in the normal aging process. Aberrant AMP expression may participate in the onset and development of AD by inducing or accelerating Aβ deposition. These findings suggest that AMPs may serve as potential diagnostic biomarkers and therapeutic targets. However, further studies are required to elucidate the pathological effects and underlying mechanisms of AMP dysregulation in AD progression.
Topics & Concepts
Drosophila melanogasterBiologyNeurodegenerationDiseaseIn silicoImmune systemGeneGene expressionAntimicrobial peptidesAgeingInnate immune systemTransgeneImmune dysregulationImmunologyPeptideGeneticsMedicineInternal medicineBiochemistryAntimicrobial Peptides and ActivitiesProtein Hydrolysis and Bioactive PeptidesS100 Proteins and Annexins