Piperine inhibits AML-12 hepatocyte EMT and LX-2 HSC activation and alleviates mouse liver fibrosis provoked by CCl<sub>4</sub>: roles in the activation of the Nrf2 cascade and subsequent suppression of the TGF-β1/Smad axis
Guangwen Shu, Arslan Yusuf, Chenxi Dai, Hui Sun, Xukun Deng
Abstract
. PIP modulated the intrahepatic contents of the markers of EMT and HSC activation. In mouse livers, PIP activated Nrf2 signaling and reduced Smad2/3-dependent gene transcriptions. Our findings collectively suggested PIP as a new chemical entity with the capacity of alleviating liver fibrosis. The activation of the Nrf2 cascade and subsequent suppression of the TGF-β1/Smad axis are implicated in the hepatoprotective activity of PIP.
Topics & Concepts
SMADHepatocyteGene knockdownPiperineChemistryCancer researchFibrosisPhosphorylationSignal transductionHepatic fibrosisCell biologyBiologyIn vitroInternal medicineGeneMedicineBiochemistryOrganic chemistryLiver physiology and pathologyLiver Disease Diagnosis and TreatmentDrug Transport and Resistance Mechanisms