Design, synthesis and evaluation of new quinazolin-4-one derivatives as apoptotic enhancers and autophagy inhibitors with potent antitumor activity
Heba S. A. Elzahabi, Mohamed S. Nafie, Dina A. Osman, Nehal H. Elghazawy, Dalia H. Soliman, Abdel‐Ghany A. El‐Helby, Reem K. Arafa
Topics & Concepts
ChemistryApoptosisPI3K/AKT/mTOR pathwayAutophagyProtein kinase BPumaCell cycle checkpointCancer cellProgrammed cell deathCell cycleDocking (animal)Cytotoxic T cellIn vivoIntrinsic apoptosisPharmacologyCancer researchCaspaseCancerIn vitroBiochemistryBiologyNursingMedicineBiotechnologyGeneticsQuinazolinone synthesis and applicationsCancer therapeutics and mechanismsSynthesis and Characterization of Heterocyclic Compounds