The Utility of Native MS for Understanding the Mechanism of Action of Repurposed Therapeutics in COVID-19: Heparin as a Disruptor of the SARS-CoV-2 Interaction with Its Host Cell Receptor
Yang Yang, Yi Du, Igor A. Kaltashov
Abstract
ACE2 and the heparin segments not accommodated on the RBD surface. In addition to providing important mechanistic information on attenuation of the ACE2/RBD association by heparin, the study demonstrates the yet untapped potential of native MS coupled to gas-phase ion chemistry as a means of facilitating rational repurposing of the existing medicines for treating COVID-19.
Topics & Concepts
ChemistryDocking (animal)Computational biologySevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)ReceptorCoronavirus disease 2019 (COVID-19)Mechanism (biology)BiophysicsViral entryBinding siteMechanism of actionVirusBiochemistryVirologyViral replicationBiologyIn vitroInfectious disease (medical specialty)PathologyMedicineNursingDiseasePhilosophyEpistemologyMass Spectrometry Techniques and ApplicationsSARS-CoV-2 and COVID-19 ResearchInfluenza Virus Research Studies