Spermidine rescues the deregulated autophagic response to oxidative stress of osteoarthritic chondrocytes
Stefania D’Adamo, Silvia Cetrullo, Serena Guidotti, Ylenia Silvestri, Manuela Minguzzi, Spartaco Santi, Luca Cattini, Giuseppe Filardo, Flavio Flamigni, Rosa Maria Borzı̀
Topics & Concepts
AutophagyCell biologySpermidineChemistryMitophagyOxidative stressATG5Gene silencingProgrammed cell deathOsteoarthritisViability assayChondrocyteCellApoptosisBiologyBiochemistryMedicineIn vitroPathologyGeneEnzymeAlternative medicineAutophagy in Disease and TherapyAntimicrobial Peptides and ActivitiesOsteoarthritis Treatment and Mechanisms