Myosin 5b is required for proper localization of the intermicrovillar adhesion complex in the intestinal brush border
Sarah Dooley, Kristen A. Engevik, Jessica Digrazia, Rachel Stubler, Izumi Kaji, Evan Krystofiak, Amy C. Engevik
2022American Journal of Physiology-Gastrointestinal and Liver Physiology12 citationsDOIOpen Access PDF
Abstract
The intestinal epithelium absorbs nutrients and water through an elaborate apical membrane of highly organized microvilli. Microvilli organization is regulated by the intermicrovillar adhesion complexes, which create links between neighboring microvilli and control microvilli packing and density. In this study, we report a new trafficking partner of the IMAC, Myosin 5b. Loss of Myosin 5b results in a disorganized brush border and failure of IMAC proteins to reach the distal tips of microvilli.
Topics & Concepts
Apical membraneBrush borderCell biologyVillinMyosinBiologyActinChemistryMembraneBiochemistryVesicleTissue Engineering and Regenerative MedicineCancer Cells and MetastasisCongenital gastrointestinal and neural anomalies