ACT001 reduces the expression of PD-L1 by inhibiting the phosphorylation of STAT3 in glioblastoma
Luqing Tong, Jiabo Li, Qiuying Li, Xuya Wang, Ravi Medikonda, Tianna Zhao, Tao Li, Haiwen Ma, Yi Li, Peidong Liu, Yang Xie, John Choi, Shengping Yu, Yu Lin, Jun Dong, Qiang Huang, Xun Jin, Michael Lim, Xuejun Yang
Abstract
Our results demonstrate that STAT3 plays a key role in immunosuppression of glioma and is inhibited by ACT001. ACT001 inhibits PD-L1 transcription and modulates anti-tumor immune response in glioma bearing mice. These findings will help us to understand the mechanism of ACT001 in GBM therapy.
Topics & Concepts
GlioblastomaPhosphorylationCancer researchSTAT3ChemistryBiologyBiochemistryCancer Immunotherapy and BiomarkersGlioma Diagnosis and TreatmentCytokine Signaling Pathways and Interactions