Visible-light-promoted direct C3-trifluoromethylation and perfluoroalkylation of imidazopyridines
Meichen Li, Gaolin Li, Chenxun Dai, Wen‐Jun Zhou, Wenqiang Zhan, Muyang Gao, Yuan Rong, Ze Tan, Wei Deng
Abstract
An efficient method for direct trifluoromethylation and perfluoroalkylation at C3 of imidazopyridines through visible light-promoted C-H bond functionalization was developed. Under the irradiation of a blue LED, a series of C3-perfluoroalkyl-substituted imidazopyridines were synthesized from the corresponding imidazopyridines and perfluoroalkyl iodides in moderate to good yields at room temperature. It should be mentioned that this reaction proceeded in the absence of any transition-metal catalyst, oxidant and photocatalyst.
Topics & Concepts
TrifluoromethylationChemistryPhotocatalysisVisible spectrumCatalysisSurface modificationPhotochemistryCombinatorial chemistryOrganic chemistryTrifluoromethylPhysical chemistryOptoelectronicsAlkylPhysicsFluorine in Organic ChemistryRadical Photochemical ReactionsCatalytic C–H Functionalization Methods