The human gut microbiota in people with amyotrophic lateral sclerosis
Katharine Nicholson, Kjetil Bjørnevik, Galeb Abu-Ali, James Chan, Marianna Cortese, Brixhilda Dedi, Maryangel Jeon, Ramnik J. Xavier, Curtis Huttenhower, Alberto Ascherio, James D. Berry
Abstract
OBJECTIVE: The levels of several butyrate-producing bacteria, which are important for gut integrity and regulation of inflammation, were lower in people with ALS compared to controls. These findings lend support to the inference that the gut microbiota could be a risk factor for ALS. Further investigations are warranted, preferably earlier in the disease with corresponding dietary collection and a longitudinal design.
Topics & Concepts
RoseburiaGut floraAmyotrophic lateral sclerosisMetagenomicsBiologyButyrateEubacteriumRelative species abundanceDiseaseLactobacillusZoologyInternal medicineMicrobiologyPhysiologyBacteriaAbundance (ecology)ImmunologyMedicineGeneticsFood scienceEcologyGeneFermentationAmyotrophic Lateral Sclerosis ResearchGut microbiota and healthPalliative Care and End-of-Life Issues