Silencing DSCAM-AS1 suppresses the growth and invasion of ER-positive breast cancer cells by downregulating both DCTPP1 and QPRT
Yue Zhang, Jia Shusheng, Song Hongtao, Shu Zhao, Huang Lan, Qingyuan Zhang, Shaoqiang Cheng, Yuanxi Huang
Abstract
mRNA stability by binding to the 3' untranslated region, which collectively resulted in DCTPP1 overexpression. Overall, DSCAM-AS1 knockdown decreased both DCTPP1 and QPRT expression, inhibiting the growth, migration, and invasion of estrogen receptor-positive BC.
Topics & Concepts
Chromatin immunoprecipitationGene knockdownBiologyGene silencingCancer researchMolecular biologyCell biologyGene expressionGenePromoterGeneticsRNA modifications and cancerRNA Research and SplicingCancer-related molecular mechanisms research