Origins and evolution of extreme life span in Pacific Ocean rockfishes
Sree Rohit Raj Kolora, Gregory L. Owens, Juan Manuel Vázquez, Alexander L. Stubbs, Kamalakar Chatla, Conner Jainese, Katelin Seeto, Merit McCrea, Michael J. Sandel, Juliana A. Vianna, Katherine P. Maslenikov, Doris Bachtrog, James W. Orr, Milton S. Love, Peter H. Sudmant
Abstract
) exhibit extreme variation in life span, with some species being among the most long-lived extant vertebrates. We de novo assembled the genomes of 88 rockfish species and from these identified repeated signatures of positive selection in DNA repair pathways in long-lived taxa and 137 longevity-associated genes with direct effects on life span through insulin signaling and with pleiotropic effects through size and environmental adaptations. A genome-wide screen of structural variation reveals copy number expansions in the immune modulatory butyrophilin gene family in long-lived species. The evolution of different rockfish life histories is coupled to genetic diversity and reshapes the mutational spectrum driving segregating CpG→TpG variants in long-lived species. These analyses highlight the genetic innovations that underlie life history trait adaptations and, in turn, how they shape genomic diversity.