Replacement of the phosphodiester backbone between canonical nucleosides with a dirhenium carbonyl “click” linker—a new class of luminescent organometallic dinucleoside phosphate mimics
Joanna Skiba, Aleksandra Kowalczyk, Aleksander Gorski, Natalia Dutkiewicz, Magdalena Gapińska, Józef Stróżek, Krzysztof Woźniak, Damian Trzybiński, Konrad Kowalski
Abstract
A “click” synthetic approach toward first-in-class dinucleoside phosphate mimics possessing a luminescent dirhenium carbonyl linker instead of a phosphodiester entity is reported.
Topics & Concepts
LinkerChemistryCycloadditionClick chemistryHeLaPhosphodiester bondAzideSonogashira couplingStereochemistryCombinatorial chemistryBiochemistryIn vitroRNAOrganic chemistryOperating systemPalladiumComputer scienceGeneCatalysisClick Chemistry and ApplicationsAdvanced biosensing and bioanalysis techniquesDNA and Nucleic Acid Chemistry