ASPM promotes glioblastoma growth by regulating G1 restriction point progression and Wnt-β-catenin signaling
Xin Chen, Lijie Huang, Yang Yang, Suhua Chen, Jianjun Sun, Changcheng Ma, Jingcheng Xie, Yongmei Song, Jun Yang
Abstract
. Furthermore, downregulation of ASPM could arrest the cell cycle of GBM cells at the G0/G1 phase and attenuate the Wnt/β-catenin signalling activity in GBM. These data suggest that ASPM may serve as a new target for the therapeutic treatment of GBM.
Topics & Concepts
Wnt signaling pathwayBiologyCarcinogenesisCancer researchPhenotypeCateninCell cycleCell growthDownregulation and upregulationGeneGeneticsMicrotubule and mitosis dynamicsRNA modifications and cancerMicroRNA in disease regulation