An ultrasound activated cyanine-rhenium(<scp>i</scp>) complex for sonodynamic and gas synergistic therapy
Jiayi Zhu, Ai Ouyang, Jiaqi He, Juan Xie, Samya Banerjee, Qianling Zhang, Pingyu Zhang
Abstract
A novel cyanine-rhenium(I) tricarbonyl complex is developed as a potent sonosensitizer and sono-activatable CO-releasing agent for synergistic sonodynamic therapy and CO gas therapy of cancer. The complex induced ferroptosis as the mode of cell death.
Topics & Concepts
Sonodynamic therapyCyanineRheniumChemistryCancer researchOrganic chemistryMedicinePhotodynamic therapyQuantum mechanicsFluorescencePhysicsHeme Oxygenase-1 and Carbon MonoxideNanoplatforms for cancer theranosticsUltrasound and Hyperthermia Applications