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Intermittent clearance of p21-highly-expressing cells extends lifespan and confers sustained benefits to health and physical function

Binsheng Wang, Lichao Wang, Nathan Gasek, Chia‐Ling Kuo, Jia Nie, Taewan Kim, Pengyi Yan, Junyu Zhu, Blake L. Torrance, Yueying Zhou, Lisa C. Flores, Colton Allen, Allison M. Andrade, Chun Guo, Rachel Cohn, Evan R. Jellison, Jenna M. Bartley, George A. Kuchel, Sheng Li, Tamar Pirtskhalava, Tamar Tchkonia, Sumit Yadav, Laura Haynes, James L. Kirkland, Yuji Ikeno, Ming Xu

2024Cell Metabolism50 citationsDOIOpen Access PDF

Topics & Concepts

InflammationProinflammatory cytokineFunction (biology)BiologyTranscriptomeCell biologyLife extensionLongevityCancer researchPhysiologyMedicineGerontologyImmunologyGeneticsGeneGene expressionGenetics, Aging, and Longevity in Model OrganismsEpigenetics and DNA MethylationBirth, Development, and Health