Bioactive phospho-therapy with black phosphorus for <i>in vivo</i> tumor suppression
Shengyong Geng, Ting Pan, Wenhua Zhou, Haodong Cui, Lie Wu, Zhibin Li, Paul K. Chu, Xue‐Feng Yu
Abstract
Background and Purpose: Although inorganic nanomaterials have been widely used in multimodal cancer therapies, the intrinsic contributions of the materials are not well understood and sometimes underestimated. In this work, bioactive phospho-therapy with black phosphorus nanosheets (BPs) for in vivo tumor suppression is studied. Methods: Orthotopic liver tumor and acute myeloid leukemia are chosen as the models for the solid tumor and hematological tumor, respectively. BPs are injected into mice through the tail vein and tumor growth is monitored by IVIS bioluminescence imaging. Tumor tissues and serum samples are collected to determine the suppression effect and biosafety of BPs after treatment.