Continuous flow reactions in the preparation of active pharmaceutical ingredients and fine chemicals
Guilherme M. Martins, Felipe C. Braga, Pedro P. de Castro, Timothy J. Brocksom, Kléber T. de Oliveira
Abstract
Herein, we present an overview of continuous flow chemistry, including photoflow and electroflow technologies in the preparation of active pharmaceutical ingredients (APIs) and fine chemical intermediates. Examples highlighting the benefits and challenges associated with continuous flow processes, mainly involving continuous thermal, photo- and electrochemical transformations, are drawn from the relevant literature, especially our experience and collaborations in this area, with emphasis on the synthesis and prospective scale-up.
Topics & Concepts
Active ingredientChemistryContinuous flowCombinatorial chemistryFlow propertiesBiochemical engineeringPharmacologyMedicineMechanicsEngineeringPhysicsInnovative Microfluidic and Catalytic Techniques InnovationAnalytical Chemistry and ChromatographyMicrofluidic and Capillary Electrophoresis Applications