A visible light-controllable Rho kinase inhibitor based on a photochromic phenylazothiazole
Kazuya Matsuo, Sampreeth Thayyil, Mitsuyasu Kawaguchi, Hidehiko Nakagawa, Nobuyuki Tamaoki
Abstract
Rho-associated coiled-coil-containing protein kinase (ROCK) is a serine–threonine kinase whose inhibitors are useful for the regulation of the actomyosin system.
Topics & Concepts
PhotochromismIsomerizationKinaseChemistryThreonineRho-associated protein kinaseVisible spectrumPhosphorylationProtein kinase ABiophysicsIn vitroSerineCell biologyBiochemistryMaterials sciencePhotochemistryBiologyOptoelectronicsCatalysisPhotochromic and Fluorescence ChemistryPhotoreceptor and optogenetics researchRetinal Development and Disorders