(±)-Spiroganoapplanin A, a complex polycyclic meroterpenoid dimer from <i>Ganoderma applanatum</i> displaying potential against Alzheimer's disease
Xing‐Rong Peng, Rongcan Luo, Hai‐Guo Su, Lin Zhou, Xiaoqian Ran, Yarong Guo, Yong‐Gang Yao, Ming‐Hua Qiu
Abstract
(±)-spiroganoapplanin A ( 1 ) with a polycyclic meroterpenoid from Ganoderma applanatum showed potential anti-AD’s effect by reducing Aβ42 production and inhibiting Tau phosphorylation through BACE1, CDK5, and GSK3β-mediated pathways.
Topics & Concepts
ChemistryGanodermaDimerStereochemistryGanoderma lucidumOrganic chemistryFood scienceFungal Biology and ApplicationsPhytochemistry and Bioactivity StudiesCholinesterase and Neurodegenerative Diseases