Three Related Enzymes in Candida albicans Achieve Arginine- and Agmatine-Dependent Metabolism That Is Essential for Growth and Fungal Virulence
Katja Schaefer, Jeanette Wagener, Ryan M. Ames, Stella Christou, Donna M. MacCallum, Steven Bates, Neil A. R. Gow
Abstract
We show that the C. albicans ureohydrolases arginase (Car1), agmatinase (Agt1), and guanidinobutyrase (Gbu1) can orchestrate an arginase-independent route for polyamine production and that this is important for C. albicans growth and survival in microenvironments of the mammalian host.
Topics & Concepts
ArginaseAgmatineArginineCandida albicansBiologyOrnithineBiochemistryVirulencePolyamineMicrobiologyCorpus albicansMutantAmino acidGenePolyamine Metabolism and ApplicationsAntifungal resistance and susceptibilityParasitic Infections and Diagnostics