Population Pharmacokinetics and Dosage Optimization of Linezolid in Patients with Liver Dysfunction
Suhua Zhang, Zhenyu Zhu, Zi Chen, Ying Li, Yang Zou, Miao Yan, Xu Yun, Feng Wang, Mou-Ze Liu, Min Zhang, Bikui Zhang
Abstract
Linezolid is the first synthetic oxazolidone agent to treat infections caused by Gram-positive pathogens. Infected patients with liver dysfunction (LD) are more likely to suffer from adverse reactions, such as thrombocytopenia, when standard-dose linezolid is used than patients with LD who did not use linezolid. Currently, pharmacokinetics data of linezolid in patients with LD are limited. This study aimed to characterize pharmacokinetics parameters of linezolid in patients with LD, identify the factors influencing the pharmacokinetics, and propose an optimal dosage regimen.
Topics & Concepts
LinezolidPharmacokineticsMedicineRegimenPharmacologyPopulationAdverse effectAntibacterial agentAntibioticsIntensive care medicineInternal medicineBiologyMicrobiologyVancomycinStaphylococcus aureusEnvironmental healthGeneticsBacteriaAntibiotics Pharmacokinetics and EfficacyAntimicrobial Resistance in StaphylococcusVeterinary medicine and infectious diseases