Effect of the Use of Galectin-9 and Blockade of the TIM-3 Receptor in the Latent Cellular Reservoir of HIV-1
Marta Sanz, Nadia Madrid-Elena, Sergio Serrano‐Villar, Alejandro Vallejo, Carolina Gutiérrez, Santiago Moreno
Abstract
HIV-1 infection is a health problem of enormous importance that still causes significant mortality. Antiretroviral treatment (ART) has demonstrated efficacy in the control of HIV-1 replication, decreasing the morbidity and mortality of the infection, but it cannot eradicate the virus.
Topics & Concepts
BiologyCytotoxic T cellCTL*Jurkat cellsVirus latencyImmunologyBlockadeEx vivoCD8ReceptorT-cell receptorLatent VirusViral replicationVirologyImmune systemT cellIn vitroVirusBiochemistryGalectins and Cancer BiologyImmune Cell Function and InteractionPeptidase Inhibition and Analysis