Oxaliplatin and [Pt(<i>R</i>,<i>R</i>-DACH)(panobinostat<sub>-2H</sub>)] show nanomolar cytotoxicity towards diffuse intrinsic pontine glioma (DIPG)
Marie H. C. Boulet, Laura K. Marsh, Alison Howarth, Alice Woolman, Nicola J. Farrer
Abstract
O) and panobinostat (DMF) resulted in instantaneous reactivity and precipitation of a panobinostat derivative which was not a platinum complex; the same reactivity was not observed between carboplatin and panobinostat.
Topics & Concepts
PanobinostatCytotoxicityChemistryCancer researchOxaliplatinGliomaStereochemistryMedicinal chemistryMedicineInternal medicineCancerColorectal cancerBiochemistryIn vitroDNAHistone deacetylaseHistoneMetal complexes synthesis and propertiesOrganometallic Complex Synthesis and CatalysisClick Chemistry and Applications