Immunometabolism at the cornerstone of inflammaging, immunosenescence, and autoimmunity in COVID-19
Loukman Omarjee, Frédérique Perrot, Olivier Meilhac, Guillaume Mahé, Guilhem Bousquet, Anne Janin
Abstract
Inflammaging constitutes the common factor for comorbidities predisposing to severe COVID-19. Inflammaging leads to T-cell senescence, and immunosenescence is linked to autoimmune manifestations in COVID-19. As in SLE, metabolic dysregulation occurs in T-cells. Targeting this T-cell dysfunction opens the field for new therapeutic strategies to prevent severe COVID-19. Immunometabolism-mediated approaches such as rapamycin, metformin and dimethyl fumarate, may optimize COVID-19 treatment of the elderly and patients at risk for severe disease.
Topics & Concepts
ImmunosenescenceCoronavirus disease 2019 (COVID-19)CornerstoneAutoimmunity2019-20 coronavirus outbreakSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)VirologyMedicinePandemicImmunologyInfectious disease (medical specialty)Immune systemInternal medicineDiseaseGeographyArchaeologyOutbreakCOVID-19 Clinical Research StudiesInflammasome and immune disordersLong-Term Effects of COVID-19