Copper-Catalyzed Difluoroalkylation Reaction
Dao‐Qing Dong, Shaohui Yang, Wu Pei, Jinzhi Wang, Ling-Hao Min, Hao Yang, Meng‐Yu Zhou, Ze‐Hui Wei, Cai-Zhen Ding, Yanli Wang, Jia‐Hui Gao, Shujie Wang, Zu‐Li Wang
Abstract
This review describes recent advances in copper-catalyzed difluoroalkylation reactions. The RCF2 radical is generally proposed in the mechanism of these reactions. At present, various types of copper-catalyzed difluoroalkylation reactions have been realized. According to their characteristics, we classify these difluoroalkylation reactions into three types.
Topics & Concepts
CopperCatalysisChemistryCombinatorial chemistryMechanism (biology)Reaction mechanismOrganic chemistryPhysicsQuantum mechanicsFluorine in Organic ChemistryInorganic Fluorides and Related Compounds